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Neuroendocrine cells in the glands of the GASTRIC MUCOSA. They produce HISTAMINE and peptides such as CHROMOGRANINS. ECL cells respond to

In mammals they are located basally in the oxyntic gland area, in the chief-cell-rich region. Parietal cells predominate in t he mid-region. 1999-11-01 Histamine is stored primarily in the ECL cells that reside in the basal half of the oxyntic gland. 22 It is formed by the decarboxylation of histidine by histidine decarboxylase.

Ecl cells histamine

Gastrin itself is secreted by cells in the epithelium of the stomach, but travels to ECL cells via the blood. Together, histamine and gastrin are primary positive regulators of acid secretion from the parietal cell. Gastrin increases the expression of several genes in ECL cells that are important for histamine synthesis and storage; these include histidine decarboxylase (HDC), which makes histamine from histidine; vesicular monoamine transporter type (VMAT2), which transports histamine into secretory vesicles; and chromogranin A, which is co-stored with histamine in secretory vesicles (Fig. 3). The ECL-cell histamine mobilization was independent of the concentrations of Ca2+ in the perfusion medium (0-3.4 mmol/l Ca2+).

ECL-cell histamine plays an important role in the regulation of gastric acid secretion, particularly in response to gastrin stimulation. The time-course responses of ECL cells to gastrin include

The histamine response to electrical vagal stimulation reflects the effect of circulating gastrin rather than a direct action of the vagus on the ECL cells. ECL cells are endocrine/paracrine cells located in the acid-producing part of the stomach. They are important regulators of gastric acid secretion in the stomach by virtue of their histamine synthesizing and secreting capacity. Histamine and the histamine-forming enzyme histidine decarboxylase (HDC) have been claimed to occur also in the gastrin-secreting G cells in the antrum.

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They secrete histamine which is a major stimulator of acid secretion. Chormogranin A (CgA)-derived peptides, such as pancreastatin, are co-secreted with histamine. Aim: Gastrin stimulates acid secretion by mobilizing histamine from enterochromaffin‐like (ECL) cells that occur predominantly at the base of the gastric glands. The parietal cells occur higher up in the glands nearer to the gastric lumen.

Chormogranin A (CgA)-derived peptides, such as pancreastatin, are co-secreted with histamine. Histamine is mobilized from the ECL cells to stimulate acid secretion from adjacent parietal cells (Sandvik et al. 1987; Håkanson & Sundler, 1991; Waldum et al. 1991). In addition, both ECL cells and parietal cells are thought to operate under nervous control.
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Finally, Feb 16, 2016 The gastrin (from G-cells) stimulates the ECL cells to produce and secrete histamine while, in a reciprocal way, this histamine (from ECL cells), The histamine-storing ECL cells in the stomach play a key role in the control of acid secretion.

This study investigates the underlying signaling events in this neuroendocrine cell type. In ECL cells, RT-PCR suggested the presence of inositol 1,4,5-trisphosphate receptor (IP (3)R) subtypes 1-3.
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ECL cells respond to food intake or vagal nerve stimulation by releasing histamine (8), but the number of these cells is insignificant in the antral stomach. Finally,

Results: The ECL cell carries the gastrin receptor, and gastrin regulates its function (histamine release) as well as proliferation. Long-term hypergastrinemia results in gastric neoplasia of variable malignancies, implying that gastric hypoacidity resulting in increased gastrin release will induce gastric neoplasia, including gastric cancer. HISTAMINE SECRETION FROM ECL CELLS Histamine secretion from ECL cells is of critical importance for gastric acid secretion. In vivo studies have shown that the antral hormone gastrin is the main stimulus for acid secretion and histamine release. This hormone is released from gastrin (G) cells of the antrum after food uptake and binds to “Enterochromaffin-like (ECL) cells” are a population of cells that are found in the gastric pits of the stomach luminal epithelium and secrete histamine. In response to gastrin released by neighbouring G-cells, secreted histamine from ECL cells acts on parietal cells to stimulate the release of gastric acid.